Diosmin, Micronized, Diosmin Hesperidin
Product Name: Diosmin
Herb Source: Citrua aurantium L.
Specification: 99%, 98%, 95%, 90%
Appearance: Light Yellow Powder
Test Method: HPLC
Molecular Formula & Molecular Weight: C28H32O15 ; 608.54
Melting Point & Solubility:Almost insoluble in water, soluble in DMSO, almost insoluble in ethanol, soluble in dilute alkaline solution.
Pharmacology:Treatment of venous lymphatic insufficiency associated symptoms (heavy legs, pain, discomfort, soreness early morning) - the treatment of acute hemorrhoid attack on a variety of symptoms. With vitamin P-like effects, can reduce vascular fragility and abnormal permeability, but also for the control of the adjuvant treatment of hypertension and arteriosclerosis, for the treatment of capillary fragility was better than rutin, hesperidin and stronger, and has low toxicity characteristics. Of the vein system to play its active role in: - reduce venous distensibility and venous stasis zone. - In the micro-circulatory system, so that the normalization of capillary wall permeability and increase their resistance.
What Is Diosmin ?
Diosmin is a naturally occurring flavonoid glycoside that can be isolated from various plant sources or derived from the flavonoid hesperidin. Diosmin was first isolated in 1925 from Scrophularia nodosa, and first introduced as a therapeutic agent in 1969. Diosmin is a biogenic amine derived by extracting hesperidin from Citrus Aurantium L., followed by conversion of hesperidin to diosmin. Diosmin is considered to be a vascular-protecting agent used to treat chronic venous insufficiency, hemorrhoids, lymphedema, and varicose veins. As a flavonoid, diosmin also exhibits anti-inflammatory, free-radical scavenging, and antimutagenic properties. Diosmin has been used for more than 30 years as a phlebotonic and vascular protecting agent, and has recently begun to be investigated for other therapeutic purposes, including cancer, premenstrual syndrome, colitis, and diabetes.
Main Functions and Benefits of Diosmin
1. Diosmin prolongs the vasoconstrictor effect of norepinephrine on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis.
2. Diosmin increases the venous return and reduces venous hyperpressure present in patients suffering from CVI.
3. Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries.
4. Diosmin powder with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure.
5. At the microcirculation level, diosmin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from damaging processes.
6. Diosmin reduces the expression of endothelial adhesion molecules,and inhibits the adhesion, migration, and activation of leukocytes at the capillary level. Diosmin powder leads to a reduction in the release of inflammatory mediators, principally oxygen free radicals and prostaglandins.
Applications of Diosmin
1. Diosmin can be used as raw material for medicines in pharmaceutical field.
2. Diosmin can be used as raw material in health care product and supplement field.
Package & Storage
1. 1-5kg with double plastic container inside/aluminum foil bag outside. 10kg with double plastic container inside/carton outside. 25kg with double plastic container inside/fiber drum outside or it is at your option.
2. Stored in a cool & dry well-closed container, keep away from moisture and strong light/heat.
3. Shelf Life: Two years under well storage situation.
Transport & Payment
1. Small package sent by EMS, UPS, FedEx, DHL, etc.
2. Cargo sent by Air or By Sea is all available.
3. Payment available for Western Union, T/T, Paypal, etc.
1. Plant extraction manufactory with factory covers an area of 35000 square maters.
2. Meet your special demand of product specification and demands on capsules, softgels, tablets and powder blendings.
3. Certificates: ISO9001, Kosher, Halal, ISO9001, HACCP, QS, NOP and Chinese Health Food GMP, etc.
4. Our purpose: provide you product with best quality, excellent service and prompt delivery with over 15 years' production and research experiences in high quality natural ingredients.
5. Rich experiences on export business; the products and services have been widely accepted by clients of USA, Europe and Australia, etc.
Every year, our team attends many industry related exhibitions around the world, such as CPHI in Shanghai, China and Spain, Vitafood in Switzerland, Engredea/NPEW in the USA, etc.
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